Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31253416 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6171595 | 0.86 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8987324 | 0.83 | HPGD (0.68) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL25652542 | 0.80 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL12277483 | 0.80 | RXFP1 (0.67) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1757943 | 0.80 | MEN1 (0.62) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7523167 | 0.79 | ALDH1A1 (0.78) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1771735 | 0.77 | KDM4E (0.57) | SMN1; SMN2ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL5514658 | 0.77 | MAPT (0.53) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL25652535 | 0.76 | RXFP1 (0.45) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137751-A1 | METHODS OF TREATING ADVANCED SOLID TUMORS | KURA ONCOLOGY, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | KURA ONCOLOGY, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | WUXI APPTEC (HONG KONG) LIMITED (CN) | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | FNTA, FDPS, GGPS1 | SMN1; SMN2 4108/4885MEN1 72/4885KMT2A 4281/4885 |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | FNTA, FDPS, GGPS1 | SMN1; SMN2 4108/4885MEN1 72/4885KMT2A 4281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.