Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749178 | 0.89 | CYP19A1 (0.38) | CYP19A1MEN1KMT2ACYP26A1 | |
| SCHEMBL6999923 | 0.75 | CYP19A1 (0.38) | CYP19A1MEN1KMT2ACYP26A1 | |
| SCHEMBL11202221 | 0.71 | HSP90AA1 (0.38) | CYP19A1MEN1KMT2A | |
| SCHEMBL2648843 | 0.69 | CYP19A1 (0.35) | CYP19A1 | |
| SCHEMBL8453886 | 0.63 | — | — | |
| SCHEMBL5306513 | 0.63 | FAAH (0.49) | CYP19A1MEN1KMT2ACYP26A1 | |
| SCHEMBL502219 | 0.62 | CYP1A2 (0.43) | CYP19A1MEN1KMT2A | |
| SCHEMBL2656742 | 0.62 | MAPT (0.33) | CYP19A1MEN1KMT2A | |
| SCHEMBL20981285 | 0.62 | CYP19A1 (0.38) | CYP19A1MEN1KMT2ACYP26A1 | |
| SCHEMBL15688936 | 0.62 | CYP19A1 (0.38) | CYP19A1MEN1KMT2ACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333336-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTORS AS ANTICONVULSANTS FORMING THE COMPOUND BY AMIDATION | MERCK SHARP & DOHME LTD. (GB) | 2001-12-25 | — | — | US | disclosed |
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |