Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658946 | 0.78 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2656211 | 0.78 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6999952 | 0.77 | GABRG2 (0.65) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6995201 | 0.77 | GABRG2 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7003307 | 0.77 | — | — | |
| SCHEMBL7002532 | 0.76 | — | — | |
| SCHEMBL7003302 | 0.72 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2655667 | 0.71 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7002523 | 0.71 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7006675 | 0.70 | LRRK2 (0.35) | GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |
| US-6297235-B1 | ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2001-10-02 | — | — | US | disclosed |
| EP-1107967-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012505-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |