Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 14/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.61 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656368 | 0.90 | GABRG2 (0.60) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL6997776 | 0.85 | GABRA1 (0.61) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL2658710 | 0.85 | GABRA1 (0.58) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL2656211 | 0.85 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL2658946 | 0.83 | GABRG2 (0.62) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL7095166 | 0.83 | GABRA1 (0.65) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL6999952 | 0.82 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL7001889 | 0.81 | GABRA1 (0.62) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL2656307 | 0.81 | GABRA1 (0.62) | GABRG2GABRB3GABRA3GABRA2GABRA1 | |
| SCHEMBL340728 | 0.79 | GABRA1 (0.69) | GABRG2GABRB3GABRA3GABRA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |