Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456554 | 0.85 | KMT2A (0.37) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL2656449 | 0.84 | TSHR (0.38) | ALDH1A1KDM4ERAB9AMAPTMEN1 | |
| SCHEMBL2666550 | 0.82 | PORCN (0.37) | KMT2AGCK | |
| SCHEMBL2666711 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL2666573 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL2666668 | 0.80 | HCRTR1 (0.39) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL2666710 | 0.78 | MAPK1 (0.40) | ALDH1A1KDM4ERAB9AMAPTMEN1 | |
| SCHEMBL2666708 | 0.76 | GCK (0.43) | GCK | |
| SCHEMBL2666539 | 0.76 | MEN1 (0.43) | ALDH1A1KDM4EHPGDRAB9AMAPT | |
| SCHEMBL2644477 | 0.75 | OPRM1 (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960386-A2 | SUBSTITUTED CYCLOALKYLPYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-27 | — | — | EP | claimed |
| WO-2007053765-A2 | SUBSTITUTED CYCLOALKYLPYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | claimed |