Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 16/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004341 | 0.92 | GABRA1 (0.53) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2658323 | 0.89 | GABRG2 (0.50) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7001797 | 0.88 | GABRG2 (0.51) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2656760 | 0.83 | GABRA1 (0.45) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7003230 | 0.83 | GABRA1 (0.49) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2658048 | 0.82 | GABRA1 (0.42) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2657300 | 0.79 | GABRG2 (0.68) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2658887 | 0.77 | GABRG2 (0.47) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7001086 | 0.76 | GABRA1 (0.46) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7003200 | 0.76 | GABRA1 (0.49) | GABRG2GABRB3GABRA1GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |
| EP-1107967-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012505-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |