Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 16/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658042 | 0.88 | GABRG2 (0.51) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7004341 | 0.88 | GABRA1 (0.53) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2658323 | 0.85 | GABRG2 (0.50) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2655709 | 0.83 | GABRA1 (0.51) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2655353 | 0.83 | GABRA1 (0.45) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7001803 | 0.81 | GABRA1 (0.43) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2659141 | 0.79 | GABRG2 (0.72) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL7477660 | 0.78 | GABRG2 (0.54) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2657453 | 0.76 | GABRG2 (0.49) | GABRG2GABRB3GABRA1GABRA3GABRA2 | |
| SCHEMBL2658363 | 0.76 | GABRA1 (0.49) | GABRG2GABRB3GABRA1GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |