Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 9/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13645800 | 0.86 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL26580976 | 0.84 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL169753 | 0.84 | SMN1; SMN2 (0.63) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL27557523 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL6445371 | 0.79 | KCNH2 (0.67) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL28215465 | 0.79 | SMN1; SMN2 (0.53) | KDM4EALDH1A1SMN1; SMN2SYKPARP10 | |
| SCHEMBL17712565 | 0.78 | SYK (0.58) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL5427122 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL15474231 | 0.77 | SYK (0.51) | KDM4EALDH1A1SMN1; SMN2SYKAURKB | |
| SCHEMBL22967393 | 0.76 | ALDH1A1 (0.63) | KDM4EALDH1A1SMN1; SMN2SYKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928126-B | Amide derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-106928126-A | A kind of amide derivatives and preparation method thereof and application pharmaceutically | 四川海思科制药有限公司 | 2017-07-07 | — | — | CN | disclosed |