Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658957 | 0.75 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659707 | 0.74 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658230 | 0.73 | GABRA1 (0.37) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5773692 | 0.71 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658163 | 0.69 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659942 | 0.66 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2661888 | 0.66 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5775348 | 0.65 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658248 | 0.62 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL4005024 | 0.60 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004065388-A1 | FLUOROIMIDAZOPYRIMIDINES AS GABA-A ALPHA 2/3 LIGANDS FOR DEPRESSION/ANXIETY | MERCK SHARP & DOHME LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |