⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028847 | 0.75 | — | — | |
| SCHEMBL2658696 | 0.75 | — | — | |
| SCHEMBL12399246 | 0.64 | KCNA4 (0.31) | — | |
| SCHEMBL10400494 | 0.61 | NPSR1 (0.31) | — | |
| SCHEMBL2657443 | 0.59 | KCNA4 (0.31) | — | |
| SCHEMBL1829037 | 0.58 | FFAR3 (0.35) | — | |
| SCHEMBL877771 | 0.58 | FFAR3 (0.35) | — | |
| SCHEMBL20641019 | 0.57 | GLS (0.33) | — | |
| SCHEMBL28856371 | 0.56 | PKM (0.33) | — | |
| SCHEMBL2035911 | 0.56 | FFAR3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209778-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | Array Biopharma, Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009042435-A1 | PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | ARRAY BIOPHARMA INC. (US) | 2009-04-02 | — | — | WO | disclosed |