Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PKLR | P30613 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661008 | 0.90 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2PPARG | |
| SCHEMBL2660248 | 0.90 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2PPARG | |
| SCHEMBL2659954 | 0.88 | NSD2 (0.32) | NSD2HDAC3HDAC1PLCG2PPARG | |
| SCHEMBL2659423 | 0.83 | HRH4 (0.32) | NSD2HDAC3HDAC1PLCG2HRH4 | |
| SCHEMBL2659015 | 0.82 | HDAC3 (0.32) | NSD2HDAC3HDAC1PLCG2HRH4 | |
| SCHEMBL2659614 | 0.82 | NAMPT (0.37) | LMNATP53THRBNAMPT | |
| SCHEMBL2660563 | 0.78 | HDAC3 (0.36) | NSD2HDAC3HDAC1PLCG2PPARG | |
| SCHEMBL2659696 | 0.78 | NSD2 (0.37) | NSD2HDAC3HDAC1PLCG2PPARG | |
| SCHEMBL2659436 | 0.78 | PLCG2 (0.36) | PLCG2PPARGPPARDPPARAMAPT | |
| SCHEMBL2661595 | 0.78 | BDKRB1 (0.32) | HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |