Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659714 | 0.96 | SLC40A1 (0.38) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2659586 | 0.92 | MAPT (0.36) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2660615 | 0.90 | SLC40A1 (0.47) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2659672 | 0.90 | SLC40A1 (0.37) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2661053 | 0.87 | SLC40A1 (0.35) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2660887 | 0.87 | SLC40A1 (0.35) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2660085 | 0.86 | POLB (0.41) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2659893 | 0.86 | SLC40A1 (0.35) | SLC40A1MAPTTP53MEN1KMT2A | |
| SCHEMBL2659731 | 0.85 | METAP2 (0.43) | SLC40A1 | |
| SCHEMBL2660175 | 0.83 | MAPT (0.35) | SLC40A1MAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |