Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659355 | 0.91 | MMP2 (0.38) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2659714 | 0.91 | SLC40A1 (0.38) | POLBSLC40A1LMNAHPGDALDH1A1 | |
| SCHEMBL2660421 | 0.91 | LMNA (0.45) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2659926 | 0.87 | SLC40A1 (0.41) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2659522 | 0.86 | SLC40A1 (0.38) | POLBSLC40A1LMNAHPGDALDH1A1 | |
| SCHEMBL2659586 | 0.85 | MAPT (0.36) | POLBSLC40A1LMNAHPGDALDH1A1 | |
| SCHEMBL2661711 | 0.85 | POLB (0.38) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2660187 | 0.84 | POLB (0.38) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2660371 | 0.84 | POLB (0.37) | POLBSLC40A1LMNAHPGDKDM4E | |
| SCHEMBL2659240 | 0.83 | POLB (0.50) | POLBSLC40A1LMNAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |