Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 6/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31401292 | 1.00 | LPL (0.37) | LPLLIPGJAK2BTKRAB9A | |
| SCHEMBL20968600 | 0.86 | LIPG (0.49) | LPLLIPGJAK2BTK | |
| SCHEMBL2659046 | 0.85 | CYP17A1 (0.40) | LPLLIPGBACE1GCKALDH1A1 | |
| SCHEMBL18059705 | 0.79 | FEN1 (0.43) | LPLLIPG | |
| SCHEMBL24630498 | 0.79 | LPL (0.46) | LPLLIPGJAK2BTK | |
| SCHEMBL2659000 | 0.77 | KDM4E (0.35) | LPLLIPGJAK2BTKRAB9A | |
| SCHEMBL22040321 | 0.77 | PDK2 (0.42) | BTK | |
| SCHEMBL2661309 | 0.77 | LPL (0.37) | LPLLIPGRAB9ANPC1MAPK14 | |
| SCHEMBL22040947 | 0.76 | BRD4 (0.35) | LPLLIPGJAK2BTKBACE1 | |
| SCHEMBL24842500 | 0.76 | LPL (0.36) | LPLLIPGJAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043930-A1 | QUINOLINE DERIVATIVES WHICH ENHANCE COGNITION VIA THE GABA-A RECEPTOR | MERCK SHARP & DOHME LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |