Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660248 | 0.92 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2661008 | 0.89 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2659433 | 0.88 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2661515 | 0.83 | MAPK8 (0.33) | MAPK8MAPK10MAPTUSP2ALDH1A1 | |
| SCHEMBL2659614 | 0.79 | NAMPT (0.37) | — | |
| SCHEMBL2659874 | 0.79 | KDM4E (0.41) | HDAC3HDAC1MAPTALDH1A1 | |
| SCHEMBL2659956 | 0.78 | PLCG2 (0.35) | PLCG2MAPTUSP2ALDH1A1GAA | |
| SCHEMBL2659696 | 0.78 | NSD2 (0.37) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2660563 | 0.78 | HDAC3 (0.36) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2659227 | 0.77 | NSD2 (0.35) | NSD2HDAC3HDAC1PLCG2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |