Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPFFR1 | Q9GZQ6 | 4/20 | 0.37 |
| ▸ | NPFFR2 | Q9Y5X5 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659433 | 0.82 | NSD2 (0.33) | NAMPTLMNATP53THRB | |
| SCHEMBL2661008 | 0.80 | NSD2 (0.33) | — | |
| SCHEMBL2660248 | 0.80 | NSD2 (0.33) | RAB9A | |
| SCHEMBL2659954 | 0.79 | NSD2 (0.32) | — | |
| SCHEMBL2661515 | 0.78 | MAPK8 (0.33) | LMNATP53RAB9A | |
| SCHEMBL2659616 | 0.77 | CCR5 (0.40) | NAMPTLMNATP53NPFFR1NPFFR2 | |
| SCHEMBL2660564 | 0.76 | KDM4E (0.37) | LMNARAB9A | |
| SCHEMBL2659423 | 0.76 | HRH4 (0.32) | LMNATP53PKMTHRB | |
| SCHEMBL2659185 | 0.76 | HPGD (0.40) | — | |
| SCHEMBL2659015 | 0.76 | HDAC3 (0.32) | LMNATP53PKMTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |