Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650240 | 0.94 | MAPT (0.44) | THRBMAPTHPGDALDH1A1SLC2A1 | |
| SCHEMBL2661269 | 0.87 | NPC1 (0.41) | PTGER4NPC1GAA | |
| SCHEMBL2661874 | 0.86 | MAPT (0.46) | THRBMAPTHPGDALDH1A1AKR1C4 | |
| SCHEMBL5780492 | 0.84 | MAPT (0.46) | THRBMAPTHPGDALDH1A1SLC2A1 | |
| SCHEMBL2652875 | 0.82 | THRB (0.47) | THRBMAPTHPGDALDH1A1SLC2A1 | |
| SCHEMBL2661830 | 0.81 | MAPT (0.45) | THRBMAPTHPGDALDH1A1AKR1C4 | |
| SCHEMBL2662423 | 0.80 | LMNA (0.48) | THRBMAPTHPGDALDH1A1RAB9A | |
| SCHEMBL2662596 | 0.77 | MAPT (0.42) | THRBMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL2661601 | 0.76 | MAPT (0.47) | THRBMAPTHPGDALDH1A1AKR1C4 | |
| SCHEMBL4702845 | 0.76 | MAPT (0.46) | THRBMAPTHPGDALDH1A1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002050057-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GABA-ALPHA MEDIATED DISORDERS | NEUROSEARCH A/S (DK) | 2002-06-27 | — | — | WO | disclosed |