Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | NPY1R | P25929 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660052 | 0.87 | THRB (0.44) | NPC1GAAPTGER4 | |
| SCHEMBL2661450 | 0.85 | TSHR (0.44) | NPC1GAAGFERPTGER4DRD4 | |
| SCHEMBL2652095 | 0.82 | HDAC3 (0.44) | NPC1GAAGFERPTGER4DRD2 | |
| SCHEMBL2653718 | 0.81 | PTGER4 (0.42) | NPC1GAAGFERPTGER4DRD2 | |
| SCHEMBL2650240 | 0.80 | MAPT (0.44) | NPC1GAAPTGER4 | |
| SCHEMBL2651242 | 0.79 | TSHR (0.43) | NPC1GAAGFERPTGER4DRD2 | |
| SCHEMBL2661824 | 0.79 | ALDH1A1 (0.46) | NPC1GAAGFERPTGER4DRD2 | |
| SCHEMBL2651644 | 0.76 | JAK2 (0.42) | NPC1GAAGFERDRD4JAK2 | |
| SCHEMBL2650037 | 0.76 | TSHR (0.42) | NPC1GAAGFERDRD4CDC25B | |
| SCHEMBL2651053 | 0.75 | FGFR1 (0.48) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002050057-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GABA-ALPHA MEDIATED DISORDERS | NEUROSEARCH A/S (DK) | 2002-06-27 | — | — | WO | disclosed |