Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PYGL | P06737 | 2/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660687 | 0.89 | SIRT2 (0.39) | MAPTPYGLTAS1R3TAS1R1CTNNB1 | |
| SCHEMBL2660175 | 0.83 | MAPT (0.35) | MAPTLMNATP53THRBSLC40A1 | |
| SCHEMBL2660335 | 0.83 | MAPT (0.34) | MAPTLMNATP53THRBSLC40A1 | |
| SCHEMBL2661032 | 0.82 | MAPT (0.35) | MAPTLMNATP53THRBSLC40A1 | |
| SCHEMBL2659522 | 0.82 | SLC40A1 (0.38) | MAPTLMNATP53THRBSETD2 | |
| SCHEMBL2659634 | 0.81 | MAPT (0.34) | MAPTLMNATP53THRBSLC40A1 | |
| SCHEMBL2660662 | 0.81 | MAPT (0.34) | MAPTLMNATP53THRBSETD2 | |
| SCHEMBL2659586 | 0.80 | MAPT (0.36) | MAPTLMNATP53THRBSETD2 | |
| SCHEMBL2660118 | 0.79 | MAPT (0.40) | MAPTPYGLFTOELANETAS1R3 | |
| SCHEMBL2659714 | 0.79 | SLC40A1 (0.38) | MAPTLMNATP53THRBSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |