Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660662 | 0.92 | MAPT (0.34) | MAPTLMNATP53THRBRAB9A | |
| SCHEMBL2660175 | 0.81 | MAPT (0.35) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL2661032 | 0.81 | MAPT (0.35) | MAPTLMNATP53THRBRAB9A | |
| SCHEMBL2660116 | 0.81 | MAPT (0.41) | MAPTLMNATP53THRBSLC40A1 | |
| SCHEMBL2659522 | 0.81 | SLC40A1 (0.38) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL2659636 | 0.81 | MAPT (0.34) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL2660335 | 0.80 | MAPT (0.34) | MAPTLMNATP53THRBRAB9A | |
| SCHEMBL2659586 | 0.79 | MAPT (0.36) | MAPTLMNATP53THRBALDH1A1 | |
| SCHEMBL2659404 | 0.78 | LMNA (0.33) | MAPTLMNATP53THRBITGB3 | |
| SCHEMBL2659714 | 0.77 | SLC40A1 (0.38) | MAPTLMNATP53THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |