Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.45 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.45 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.45 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.45 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080091 | 0.82 | METAP2 (0.59) | METAP2XDHHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL29629017 | 0.82 | HTR7 (0.64) | HTR7CYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL26556078 | 0.82 | HTR7 (0.64) | HTR7CYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL5468496 | 0.80 | IDO1 (0.37) | METAP2CYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL1761759 | 0.79 | KDR (0.48) | HTR7GRM5 | |
| SCHEMBL13710416 | 0.78 | SCN9A (0.48) | CYP1A2CYP3A4CYP2D6CYP2A6CYP2C9 | |
| SCHEMBL29484275 | 0.77 | GP6 (0.46) | CYP1A2 | |
| SCHEMBL17900086 | 0.77 | GP6 (0.46) | CYP1A2 | |
| SCHEMBL17279904 | 0.76 | HSD17B10 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12782331 | 0.76 | MAPT (0.52) | CYP1A1CYP1A2CYP2E1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948614-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061923-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-05-31 | — | — | WO | disclosed |