Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.43 |
| ▸ | CBFB | Q13951 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993258 | 0.76 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL4753598 | 0.75 | CNR2 (0.37) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL10062975 | 0.73 | MAP4K4 (0.59) | GAAMAPTHTTMAP4K4MKNK1 | |
| SCHEMBL3900914 | 0.71 | CHEK1 (0.43) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL30968134 | 0.71 | MAP4K4 (0.57) | GAAMAPTHTTMAP4K4MKNK1 | |
| SCHEMBL27401952 | 0.70 | NPC1 (0.47) | ALDH1A1GAAMAPTHPGDMAP4K4 | |
| SCHEMBL4753596 | 0.70 | ALDH1A1 (0.42) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL22014607 | 0.70 | ALDH1A1 (0.39) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL27657404 | 0.68 | MAP4K4 (0.42) | MAPTHTTMAP4K4MKNK1MKNK2 | |
| SCHEMBL16432027 | 0.68 | MAP4K4 (0.53) | GAAMAPTHTTMAP4K4MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013204-A2 | 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | Array Biopharma, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007117381-A9 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007117381-A2 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-10-18 | — | — | WO | disclosed |