Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.47 |
| ▸ | CBFB | Q13951 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135064 | 0.76 | HPGD (0.67) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL2660255 | 0.76 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL2659245 | 0.73 | BCAT2 (0.49) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL1094712 | 0.73 | ALDH1A1 (0.45) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL4753598 | 0.72 | CNR2 (0.37) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL6989282 | 0.72 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL2204601 | 0.70 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTHPGDHTT | |
| SCHEMBL27288986 | 0.68 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTHPGDL3MBTL1 | |
| SCHEMBL11953304 | 0.68 | LIMK1 (0.54) | ALDH1A1GAAMAPTL3MBTL1HSD17B10 | |
| SCHEMBL16600088 | 0.67 | ALDH1A1 (0.57) | ALDH1A1GAAMAPTL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353914-A2 | THERAPEUTIC CHROMONE COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353915-A2 | THERAPEUTIC CHROMAN COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353913-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002055012-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055013-A2 | THERAPEUTIC CHROMONE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055014-A2 | THERAPEUTIC CHROMAN COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |