SCHEMBL26604693

SCHEMBL26604693

O=C(Nc1ccc2nc(-c3ccc(F)c(F)c3)cn2c1)c1cccc(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.64
ALDH1A1 P00352 4/20 0.64
KMT2A Q03164 3/20 0.64
LMNA P02545 2/20 0.64
MAPT P10636 2/20 0.64
EGLN1 Q9GZT9 1/20 0.57
NR4A2 P43354 2/20 0.55
MAPK13 O15264 1/20 0.54
BRAF P15056 1/20 0.54
KDR P35968 1/20 0.54
MAPK12 P53778 1/20 0.54
MAPK11 Q15759 1/20 0.54
MAPK14 Q16539 1/20 0.54
SMN1; SMN2 Q16637 4/20 0.52
HPGD P15428 3/20 0.52
MEN1 O00255 2/20 0.52
NPC1 O15118 2/20 0.52
HTT P42858 2/20 0.52
CYP2C19 P33261 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26604695 0.91 KDM4E (0.52) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL26604713 0.89 RAB9A (0.59) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL31683245 0.89 RAB9A (0.59) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL31683201 0.85 KDM4E (0.53) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL26604699 0.85 KDM4E (0.53) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL31683094 0.84 L3MBTL1 (0.54) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL26604709 0.84 L3MBTL1 (0.54) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL26604710 0.84 MCHR1 (0.50) KDM4EALDH1A1KMT2ALMNASMN1; SMN2
SCHEMBL31683150 0.82 MAPT (0.57) KDM4EALDH1A1KMT2ALMNAMAPT
SCHEMBL26604754 0.82 MAPT (0.57) KDM4EALDH1A1KMT2ALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4265248-A1 COMPOUNDS INDUCING PRODUCTION OF PROTEINS BY IMMUNE CELLS Université Paris Cité (FR) 2023-10-25 EP disclosed
EP-4265248-A1 COMPOUNDS INDUCING PRODUCTION OF PROTEINS BY IMMUNE CELLS Université Paris Cité (FR) 2023-10-25 EP disclosed