Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13621194 | 0.80 | TDP1 (0.67) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL8136269 | 0.78 | MTNR1A (0.45) | NCF1TDP1MAPTNAMPTHDAC4 | |
| SCHEMBL16494745 | 0.78 | CYP2D6 (0.50) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL21730499 | 0.78 | MAPT (0.38) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL23173065 | 0.77 | MAPT (0.43) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL20711077 | 0.76 | TGM2 (0.41) | NCF1TDP1MAPTNAMPTHDAC4 | |
| SCHEMBL24239177 | 0.76 | TDP1 (0.50) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL13853539 | 0.75 | MAPT (0.48) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL12935918 | 0.75 | CKS1B (0.45) | NCF1TDP1MAPTNAMPTHDAC1 | |
| SCHEMBL12964152 | 0.75 | CKS1B (0.46) | NCF1TDP1MAPTNAMPTHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678144-A1 | 1,5,7-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-a RECEPTOR COMPLEX | Akzo Nobel N.V. (NL) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040131-A1 | 1,5,7-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | AKZO NOBEL N.V. (NL) | 2005-05-06 | — | — | WO | disclosed |