Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418710 | 0.82 | PARP1 (0.41) | BCAT2PARP1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL30528245 | 0.81 | BCAT2 (0.55) | CTNNB1BCAT2PARP1CSNK1A1TYRO3 | |
| SCHEMBL696661 | 0.81 | BCAT2 (0.55) | CTNNB1BCAT2PARP1CSNK1A1TYRO3 | |
| SCHEMBL30528244 | 0.81 | BCAT2 (0.55) | CTNNB1BCAT2PARP1CSNK1A1TYRO3 | |
| SCHEMBL28081509 | 0.79 | BCAT2 (0.61) | CTNNB1BCAT2CHEK2BRD4SIRT2 | |
| SCHEMBL5117078 | 0.79 | BCAT2 (0.51) | CTNNB1BCAT2PARP1CSNK1A1TYRO3 | |
| SCHEMBL3423724 | 0.77 | BCAT2 (0.42) | BCAT2AURKAPARP1CSNK1A1TYRO3 | |
| SCHEMBL3418979 | 0.76 | BCAT2 (0.41) | BCAT2CHEK2AURKAPARP1CSNK1A1 | |
| SCHEMBL7159631 | 0.76 | BCAT2 (0.41) | BCAT2BRD4AURKAPARP1CSNK1A1 | |
| SCHEMBL7159727 | 0.76 | BCAT2 (0.41) | BCAT2BRD4AURKAPARP1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756076-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121110-A1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-22 | — | — | WO | disclosed |