Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 6/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288182 | 0.89 | NFE2L2 (0.48) | CHATNFE2L2TRPA1MAOBCYP19A1 | |
| SCHEMBL288181 | 0.89 | NFE2L2 (0.48) | CHATNFE2L2TRPA1MAOBCYP19A1 | |
| SCHEMBL729545 | 0.85 | — | — | |
| SCHEMBL729544 | 0.85 | — | — | |
| SCHEMBL482795 | 0.70 | APLNR (0.33) | — | |
| SCHEMBL335864 | 0.70 | — | — | |
| Benzene SCHEMBL1225177 | 0.70 | MAOB (0.58) | CHATNFE2L2TRPA1RELAMAOB | |
| SCHEMBL2342 | 0.70 | — | — | |
| SCHEMBL28967 | 0.70 | — | — | |
| Benzene SCHEMBL1225180 | 0.70 | MAOB (0.58) | CHATNFE2L2TRPA1RELAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129654-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | Metabasis Therapeutics, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |