Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.31 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.30 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661084 | 0.92 | MCL1 (0.33) | PIK3CAUSP2USP8ITGB3ITGAV | |
| SCHEMBL2660569 | 0.90 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1POLBGAA | |
| SCHEMBL2660500 | 0.84 | KDM4E (0.36) | MCL1MEN1KMT2AGAALGALS8 | |
| SCHEMBL2660266 | 0.83 | MEN1 (0.39) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL2659586 | 0.81 | MAPT (0.36) | CHEK1CHEK2MCL1MEN1KMT2A | |
| SCHEMBL2660294 | 0.79 | NSD2 (0.37) | MEN1KMT2A | |
| SCHEMBL2660059 | 0.78 | ALDH1A1 (0.46) | USP2USP8MEN1KMT2AALDH1A1 | |
| SCHEMBL2660342 | 0.77 | — | — | |
| SCHEMBL2660539 | 0.76 | MMP13 (0.40) | MEN1KMT2AALDH1A1GAALGALS8 | |
| SCHEMBL2659681 | 0.75 | SLC40A1 (0.37) | MCL1KMT2AGAALGALS8LGALS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |