Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 4/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31345628 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDKEAP1NFE2L2 | |
| SCHEMBL26617777 | 0.83 | KDM4E (0.40) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL30682004 | 0.83 | KDM4E (0.40) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL8832314 | 0.82 | CAMKK1 (0.36) | ALDH1A1KDM4EHPGDCAMKK1CAMKK2 | |
| SCHEMBL22732187 | 0.77 | KDM4E (0.41) | ALDH1A1KDM4EHPGDKEAP1NFE2L2 | |
| SCHEMBL15205145 | 0.75 | APP (0.35) | APP | |
| SCHEMBL30503539 | 0.74 | APP (0.34) | KDM4EAPP | |
| SCHEMBL15205408 | 0.74 | APP (0.34) | KDM4EAPP | |
| SCHEMBL31347270 | 0.73 | KDM4E (0.40) | ALDH1A1KDM4EHPGDPOLBCAMKK1 | |
| SCHEMBL26105200 | 0.73 | KDM4E (0.40) | ALDH1A1KDM4EHPGDPOLBCAMKK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |