Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26617777 | 1.00 | KDM4E (0.40) | KDM4ERXFP1ABL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8832483 | 0.84 | KDM4E (0.41) | KDM4ERXFP1ALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL31345628 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDCASP1 | |
| SCHEMBL26617809 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDCASP1 | |
| SCHEMBL31497542 | 0.83 | KDM4E (0.39) | KDM4ERXFP1ABL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26984647 | 0.82 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2NR4A2HPGD | |
| SCHEMBL31466863 | 0.82 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2NR4A2HPGD | |
| SCHEMBL30612180 | 0.75 | KDM4E (0.56) | KDM4EABL1ALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL26106242 | 0.75 | KDM4E (0.56) | KDM4EABL1ALDH1A1SMN1; SMN2NR4A2 | |
| SCHEMBL31497518 | 0.74 | DGAT1 (0.39) | KDM4ERXFP1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585247-A | Bicyclic heterocyclic amide inhibitors of nav1.8 for the treatment of pain | 赛特温治疗公司 | 2025-03-07 | — | — | CN | disclosed |
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |