Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20906131 | 0.86 | PTPN2 (0.49) | PTPN2HPGDSTING1MAPTMEN1 | |
| SCHEMBL18490302 | 0.85 | OPRD1 (0.44) | PTPN2HPGDCYP3A4MAPTKDM4E | |
| SCHEMBL18490289 | 0.81 | TBXAS1 (0.41) | PTPN2STING1MAPTMEN1KMT2A | |
| SCHEMBL17080891 | 0.79 | SLC9A1 (0.53) | PTPN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL30430905 | 0.78 | ICAM1 (0.51) | PTPN2KDM4E | |
| SCHEMBL17080828 | 0.78 | ICAM1 (0.51) | PTPN2KDM4E | |
| SCHEMBL31081110 | 0.77 | ERN1 (0.46) | PTPN2STING1MAPTMEN1KMT2A | |
| SCHEMBL31081408 | 0.76 | STING1 (0.45) | PTPN2HPGDSTING1MAPTMEN1 | |
| SCHEMBL31081047 | 0.76 | STING1 (0.45) | PTPN2HPGDSTING1MAPTMEN1 | |
| SCHEMBL18069891 | 0.76 | PTPN2 (0.48) | PTPN2HPGDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023214325-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND USES THEREOF AS TET2 INHIBITORS | NOVARTIS AG (CH) | 2023-11-09 | — | — | WO | disclosed |