Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217732 | 0.78 | CYP1A2 (0.46) | ALDH1A1L3MBTL1MAPTBRD4SMN1; SMN2 | |
| SCHEMBL16486199 | 0.76 | BRD4 (0.46) | ALDH1A1MAPTBRD4SMN1; SMN2CYP1A2 | |
| SCHEMBL21384011 | 0.74 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1MAPTBRD4SMN1; SMN2 | |
| SCHEMBL20945149 | 0.74 | KDM4E (0.49) | ALDH1A1MAPTBRD4SMN1; SMN2CYP1A2 | |
| SCHEMBL924584 | 0.74 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL30814624 | 0.73 | SMN1; SMN2 (0.44) | ALDH1A1L3MBTL1MAPTBRD4SMN1; SMN2 | |
| SCHEMBL22000137 | 0.72 | ACLY (0.46) | ALDH1A1L3MBTL1BRD4KDM4ETSHR | |
| SCHEMBL10940459 | 0.72 | CYP1A2 (0.46) | ALDH1A1L3MBTL1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL2175671 | 0.71 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1BRD4SMN1; SMN2CYP1A2 | |
| SCHEMBL2175814 | 0.71 | CPT2 (0.46) | ALDH1A1L3MBTL1MAPTSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250289793-A1 | MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE | ESPERION THERAPEUTICS, INC. | 2025-09-18 | — | — | US | disclosed |
| EP-4519251-A1 | MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE | Esperion Therapeutics, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| CN-119137107-A | Macrocyclic inhibitors of ATP citrate lyase | 艾斯柏伦治疗公司 | 2024-12-13 | — | — | CN | disclosed |
| WO-2023215220-A1 | MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE | ESPERION THERAPEUTICS, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250289793-A1 | MACROCYCLIC INHIBITORS OF ATP CITRATE LYASE | ACLY, CS, ATP5ME | ALDH1A1 792/4885L3MBTL1 2585/4885MAPT 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.