Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 6/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789322 | 0.85 | CYP1B1 (0.67) | HRH3KCNH2ACHEPARP1DRD3 | |
| SCHEMBL2005658 | 0.80 | HRH3 (0.76) | HRH3KCNH2HTR3AADRA1A | |
| SCHEMBL16720956 | 0.80 | HRH3 (0.56) | HRH3KCNH2 | |
| SCHEMBL5639861 | 0.76 | ACHE (0.89) | CHEK2HRH3ACHEDRD3DRD2 | |
| SCHEMBL4463008 | 0.75 | HRH3 (0.77) | HRH3KCNH2ADRA1A | |
| SCHEMBL4462601 | 0.75 | HRH3 (0.77) | HRH3KCNH2ADRA1A | |
| SCHEMBL21018072 | 0.74 | CHEK2 (0.74) | CHEK2HRH3KCNH2ACHEDRD3 | |
| SCHEMBL9260985 | 0.74 | ACHE (0.89) | CHEK2ACHEDRD3DRD2 | |
| SCHEMBL15555742 | 0.74 | HRH3 (0.76) | HRH3KCNH2ADRA1A | |
| SCHEMBL12050716 | 0.74 | HRH3 (0.82) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079688-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008042223-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2008-04-10 | — | — | WO | disclosed |