Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.67 |
| ▸ | PARP1 | P09874 | 2/20 | 0.64 |
| ▸ | TNKS | O95271 | 1/20 | 0.64 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.64 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.64 |
| ▸ | ACHE | P22303 | 2/20 | 0.64 |
| ▸ | GUSB | P08236 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662418 | 0.85 | CHEK2 (0.55) | PARP1TNKSTNKS2PARP2HRH3 | |
| SCHEMBL9260985 | 0.84 | ACHE (0.89) | ACHEDRD3DRD2 | |
| SCHEMBL5639861 | 0.83 | ACHE (0.89) | HRH3ACHEDRD3DRD2 | |
| SCHEMBL23743193 | 0.82 | CYP1B1 (0.80) | CYP1B1PARP1TNKSTNKS2PARP2 | |
| SCHEMBL16720990 | 0.81 | KCNH2 (0.62) | PARP1HRH3KCNH2ADRA1AACHE | |
| SCHEMBL15232132 | 0.79 | CYP1B1 (0.77) | CYP1B1PARP1TNKSTNKS2PARP2 | |
| SCHEMBL2004603 | 0.78 | HRH3 (1.00) | HRH3KCNH2ADRA1A | |
| SCHEMBL11831977 | 0.78 | GUSB (1.00) | CYP1B1PARP1TNKSTNKS2PARP2 | |
| SCHEMBL2003640 | 0.77 | HRH3 (1.00) | HRH3KCNH2ADRA1A | |
| SCHEMBL5638746 | 0.77 | ACHE (1.00) | PARP1ACHEDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398483-A1 | OXYNTOMODULIN ANALOGS | Merck Sharp & Dohme Corp. (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010096142-A1 | OXYNTOMODULIN ANALOGS | MERCK SHARP & DOHME, CORP. (US) | 2010-08-26 | — | — | WO | disclosed |