Sugi Predict

Sugi Predict / Compounds / SCHEMBL26625848

SCHEMBL26625848

SCHEMBL26625848

CC[C@@H](O)CNS(=O)(=O)c1c(F)cccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GBA1 P04062 1/20 0.47
▸ SLC6A9 P48067 3/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ GAA P10253 2/20 0.38
▸ PKM P14618 2/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ LMNA P02545 2/20 0.38
▸ ITGAV P06756 1/20 0.36
▸ PER2 O15055 1/20 0.36
▸ CXCR2 P25025 2/20 0.36
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ SLC1A3 P43003 1/20 0.35
▸ SLC1A2 P43004 1/20 0.35
▸ GRIA4 P48058 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26625852 1.00 GBA1 (0.47) GBA1SLC6A9RXFP1ATMGAA
SCHEMBL22870051 0.90 GBA1 (0.52) GBA1SLC6A9GAAPKML3MBTL1
SCHEMBL31305956 0.81 GBA1 (0.50) GBA1SLC6A9GAAPKML3MBTL1
SCHEMBL26625535 0.81 GBA1 (0.50) GBA1SLC6A9GAAPKML3MBTL1
SCHEMBL26625534 0.81 GBA1 (0.50) GBA1SLC6A9GAAPKML3MBTL1
SCHEMBL29397137 0.77 GBA1 (0.76) GBA1SLC6A9ATMALDH1A1KMT2A
SCHEMBL18706602 0.77 GBA1 (0.76) GBA1SLC6A9ATMALDH1A1KMT2A
SCHEMBL16832012 0.77 GBA1 (0.76) GBA1SLC6A9ATMALDH1A1KMT2A
SCHEMBL16831474 0.76 GBA1 (0.47) GBA1PKMCA1CA2GRIA4
SCHEMBL16831477 0.76 GBA1 (0.47) GBA1PKMCA1CA2GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326770-A1 BENZOTRIAZOLE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-10-23 — — US disclosed
US-20250282724-A1 BENZOTRIAZOLE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-09-11 — — US disclosed
US-12378260-B2 Benzotriazole compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-08-05 — — US disclosed
US-20250092064-A1 BENZOTRIAZOLE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-03-20 — — US disclosed
EP-4509504-A1 BENZOTRIAZOLE COMPOUND Daiichi Sankyo Company, Limited (JP) 2025-02-19 — — EP disclosed
CN-119173511-A Benzotriazole compounds 第一三共株式会社 2024-12-20 — — CN disclosed
WO-2023210741-A1 BENZOTRIAZOLE COMPOUND 第一三共株式会社 2023-11-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250092064-A1 BENZOTRIAZOLE COMPOUND NFE2L2, BPTF, KEAP1 GBA1 1763/4885SLC6A9 3439/4885RXFP1 1802/4885
US-12378260-B2 Benzotriazole compound NFE2L2, BPTF, KEAP1 GBA1 1763/4885SLC6A9 3439/4885RXFP1 1802/4885
US-20250326770-A1 BENZOTRIAZOLE COMPOUND KEAP1, NFE2L2, TXNRD2 GBA1 2051/4885SLC6A9 2645/4885RXFP1 2361/4885
US-20250282724-A1 BENZOTRIAZOLE COMPOUND NFE2L2, BPTF, KEAP1 GBA1 1763/4885SLC6A9 3439/4885RXFP1 1802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.