Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 11/20 | 0.91 |
| ▸ | FLT3 | P36888 | 4/20 | 0.68 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CD74 | P04233 | 1/20 | 0.46 |
| ▸ | OGT | O15294 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17980671 | 0.96 | MIF (1.00) | MIFFLT3HSD17B1HSD17B2GSK3B | |
| SCHEMBL28464554 | 0.90 | FLT3 (0.73) | MIFFLT3HSD17B1HSD17B2GSK3B | |
| SCHEMBL26628323 | 0.86 | FLT3 (0.68) | MIFFLT3GSK3BGRM5OGT | |
| SCHEMBL6953018 | 0.83 | FLT3 (0.77) | MIFFLT3GSK3BGRM5NPC1 | |
| SCHEMBL27166024 | 0.81 | FLT3 (0.64) | MIFFLT3HSD17B1HSD17B2GSK3B | |
| SCHEMBL1674373 | 0.81 | FLT3 (0.73) | MIFFLT3GSK3BGRM5NPC1 | |
| SCHEMBL29158520 | 0.81 | FLT3 (1.00) | MIFFLT3GSK3BGRM5NPC1 | |
| SCHEMBL14152110 | 0.80 | HSD17B1 (0.71) | MIFFLT3HSD17B1HSD17B2GSK3B | |
| SCHEMBL23086229 | 0.79 | HSD17B1 (0.74) | MIFHSD17B1HSD17B2CD74OGT | |
| SCHEMBL12599087 | 0.79 | HSD17B1 (0.74) | MIFFLT3HSD17B1HSD17B2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4106871-B1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIV DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO (IT) | 2024-03-13 | — | — | EP | claimed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | claimed |
| EP-4106871-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" (IT) | 2022-12-28 | — | — | EP | claimed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | claimed |
| EP-4106871-B1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIV DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO (IT) | 2024-03-13 | — | — | EP | disclosed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | disclosed |
| EP-4106871-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" (IT) | 2022-12-28 | — | — | EP | disclosed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | ORAI1, SARAF, STIM1 | MIF 1753/4885FLT3 4336/4885HSD17B1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.