Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.96 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.96 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.96 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.96 |
| ▸ | PLG | P00747 | 4/20 | 0.74 |
| ▸ | PLAU | P00749 | 1/20 | 0.74 |
| ▸ | F11 | P03951 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326662 | 0.98 | KLKB1 (1.00) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL29356307 | 0.97 | KLKB1 (0.98) | KLKB1PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7066980 | 0.83 | KLKB1 (0.73) | KLKB1PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7066988 | 0.83 | KLKB1 (0.73) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL19988160 | 0.82 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL14159641 | 0.82 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL14159640 | 0.82 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL19988159 | 0.82 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL10425156 | 0.81 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL10425157 | 0.81 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240044921-A1 | METHOD FOR EVALUATING BLOOD COAGULATION PERFORMANCE, AND METHOD FOR INSPECTING RISK OF THROMBOSIS | FUJIMORI KOGYO CO., LTD. (JP) | 2024-02-08 | — | — | US | disclosed |
| EP-4270010-A1 | METHOD FOR EVALUATING BLOOD COAGULATION PERFORMANCE, AND METHOD FOR INSPECTING RISK OF THROMBOSIS | Fujimori Kogyo Co., Ltd. (JP) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022145475-A1 | METHOD FOR EVALUATING BLOOD COAGULATION PERFORMANCE, AND METHOD FOR INSPECTING RISK OF THROMBOSIS | 藤森工業株式会社 | 2022-07-07 | — | — | WO | disclosed |