Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 2/20 | 1.00 |
| ▸ | PRSS2 | P07478 | 2/20 | 1.00 |
| ▸ | PRSS3 | P35030 | 2/20 | 1.00 |
| ▸ | PLG | P00747 | 4/20 | 0.77 |
| ▸ | PLAU | P00749 | 1/20 | 0.77 |
| ▸ | F11 | P03951 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29356307 | 0.99 | KLKB1 (0.98) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL26628958 | 0.98 | KLKB1 (0.96) | KLKB1PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7066988 | 0.84 | KLKB1 (0.73) | KLKB1PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7066980 | 0.84 | KLKB1 (0.73) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL19988159 | 0.84 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL19988160 | 0.84 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL14159640 | 0.84 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL14159641 | 0.84 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL10425157 | 0.83 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL10425156 | 0.83 | KLKB1 (0.72) | KLKB1PRSS1PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611290-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2017-04-04 | — | — | US | disclosed |
| US-20160257708-A1 | ACYLATED 4-AMIDINO- AND 4-GUANIDINOBENZYLAMINES FOR THE INHIBITION OF PLASMA KALLIKREIN | CURACYTE CHEMISTRY GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-9365613-B2 | Acylated 4-amidino- and -4-guanidinobenzylamines for inhibition of plasma kallikrein | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2016-06-14 | — | — | US | disclosed |
| EP-2528895-B1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | MEDICINES CO LEIPZIG GMBH (DE) | 2016-03-30 | — | — | EP | disclosed |
| US-8921319-B2 | Serine protease inhibitors | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-2590945-B1 | SERINE PROTEASE INHIBITORS | MEDICINES CO LEIPZIG GMBH (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-20140073573-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8598206-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-12-03 | — | — | US | disclosed |
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-10-10 | — | — | US | disclosed |
| US-8513461-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-08-20 | — | — | US | disclosed |
| EP-2590945-A2 | SERINE PROTEASE INHIBITORS | The Medicines Company (Leipzig) GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-8410310-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| EP-2528895-A2 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | The Medicines Company (Leipzig) GmbH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-20120225913-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | The Medicine Company (Leipzig) GmbH (DE) | 2012-09-06 | — | — | US | disclosed |
| US-8207378-B2 | Trypsin-like serine protease inhibitors, and their preparation and use | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| WO-2012004678-A2 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
| US-20110301196-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-12-08 | — | — | US | disclosed |
| WO-2011094496-A2 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (US) | 2011-08-04 | — | — | WO | disclosed |
| US-20100022781-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | F12, F11, F2 | KLKB1 4/4885PRSS1 128/4885PRSS2 254/4885 |
| US-20120225913-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, TFPI, SPINT2 | KLKB1 21/4885PRSS1 9/4885PRSS2 13/4885 |
| US-20140073573-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, SPINT2, SERPINB1 | KLKB1 6/4885PRSS1 7/4885PRSS2 15/4885 |
| US-20110301196-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, SPINT2, SERPINB1 | KLKB1 6/4885PRSS1 7/4885PRSS2 15/4885 |
| US-20100022781-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | SERPINE1, TFPI, SPINT2 | KLKB1 19/4885PRSS1 9/4885PRSS2 12/4885 |
| US-20160257708-A1 | ACYLATED 4-AMIDINO- AND 4-GUANIDINOBENZYLAMINES FOR THE INHIBITION OF PLASMA KALLIKREIN | F12, F2, F11 | KLKB1 4/4885PRSS1 150/4885PRSS2 316/4885 |
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | SERPINE1, KLKB1, SERPINC1 | KLKB1 2/4885PRSS1 18/4885PRSS2 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.