Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.62 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 7/20 | 0.49 |
| ▸ | GIPR | P48546 | 3/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.46 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.46 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.46 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.46 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.46 |
| ▸ | ADCY7 | P51828 | 3/20 | 0.46 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.46 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.46 |
| ▸ | ADCY4 | Q8NFM4 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ESRRG | P62508 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13800470 | 0.85 | HDAC1 (0.58) | HDAC1HDAC3HDAC2ACKR3GCGR | |
| SCHEMBL4085168 | 0.80 | GCGR (0.65) | HDAC1HDAC3HDAC2GCGRGIPR | |
| SCHEMBL2663380 | 0.74 | HDAC3 (0.47) | HDAC1HDAC3HDAC2ACKR3GCGR | |
| SCHEMBL15942950 | 0.73 | RAB9A (0.65) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2662590 | 0.73 | GCGR (0.62) | GCGRGIPRTMEM97SIGMAR1ADCY6 | |
| SCHEMBL4086646 | 0.71 | GCGR (0.46) | ACKR3GCGRGIPRADCY6ADCY3 | |
| SCHEMBL2662978 | 0.71 | GCGR (0.65) | GCGRGIPRADCY6ADCY3ADCY9 | |
| SCHEMBL14849599 | 0.71 | HDAC2 (0.52) | HDAC1HDAC3HDAC2NCOR2RAB9A | |
| SCHEMBL2410827 | 0.70 | HDAC1 (0.56) | HDAC1HDAC3HDAC2ACKR3NCOR2 | |
| SCHEMBL3538160 | 0.70 | GCGR (0.47) | GCGRGIPRTMEM97SIGMAR1ADCY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| EP-1183229-B1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK AS (DK) | 2005-10-26 | — | — | EP | disclosed |
| US-6875760-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2005-04-05 | — | — | US | disclosed |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-11-27 | — | — | US | disclosed |
| US-6503949-B1 | Treating Type 2 diabetes, hyperglycemia, impaired glucose tolerance or obesity | NORO NORDISK A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| CN-1356977-A | Glucagon antagonists/inverse agonists | NOVO NORDISK AS (DK) | 2002-07-03 | — | — | CN | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | GLP1R, GPR119, GCGR | HDAC1 2296/4885HDAC3 1068/4885HDAC2 2783/4885 |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | HDAC1 2296/4885HDAC3 1068/4885HDAC2 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.