Sugi Predict

Sugi Predict / Compounds / SCHEMBL26630686

SCHEMBL26630686

SCHEMBL26630686

NCCSc1nc2ccccc2c2cc(CNC(=O)c3ccccc3OC(F)(F)F)nn12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 1/20 0.37
▸ BTK Q06187 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.37
▸ HTT P42858 1/20 0.37
▸ F2R P25116 1/20 0.35
▸ PTGER4 P35408 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ HCN1 O60741 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ GAA P10253 1/20 0.35
▸ CSNK1E P49674 1/20 0.35
▸ ADRA2A P08913 1/20 0.35
▸ NPY5R Q15761 1/20 0.35
▸ MCHR1 Q99705 1/20 0.35
▸ TP53 P04637 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ PLG P00747 1/20 0.34
▸ KLKB1 P03952 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL30623528 0.98 EGFR (0.38) EGFRBTKALDH1A1HTTF2R
Trifluoroacetic Acid SCHEMBL26601324 0.98 EGFR (0.38) EGFRBTKALDH1A1HTTF2R
SCHEMBL31571994 0.93 KMT2A (0.41) EGFRBTKALDH1A1HTTF2R
SCHEMBL31675879 0.91 POLB (0.38) EGFRBTKALDH1A1HTTF2R
SCHEMBL26601311 0.91 POLB (0.38) EGFRBTKALDH1A1HTTF2R
SCHEMBL31461697 0.89 ALDH1A1 (0.41) EGFRBTKALDH1A1HTTF2R
SCHEMBL31461702 0.89 ALDH1A1 (0.41) EGFRBTKALDH1A1HTTF2R
SCHEMBL26629775 0.89 ALDH1A1 (0.41) EGFRBTKALDH1A1HTTF2R
SCHEMBL31675875 0.88 ACACB (0.38) ALDH1A1HTTHPGD
SCHEMBL26601312 0.88 ACACB (0.38) ALDH1A1HTTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028355-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG, KARA ANN 2026-01-29 — — US disclosed
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG, KARA ANN 2025-08-21 — — US disclosed
CN-119546341-A Proteolytic targeting chimeric (PROTAC) compositions using ubiquitin conjugated enzyme ligands 布普格生物制药公司 2025-02-28 — — CN disclosed
EP-4429705-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS Berg LLC (US) 2024-09-18 — — EP disclosed
WO-2023205219-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG LLC (US) 2023-10-26 — — WO disclosed
WO-2023205219-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG LLC (US) 2023-10-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS UBE3C, UBE3A, MDM2 EGFR 1373/4885BTK 4293/4885ALDH1A1 3014/4885
US-20260028355-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS UBE2T, UBE3C, UBE2E1 EGFR 1561/4885BTK 1151/4885ALDH1A1 3389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.