Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633384 | 0.76 | MAPT (0.59) | ALDH1A1GRM5MAPTL3MBTL1 | |
| SCHEMBL9017227 | 0.74 | MAPT (0.52) | GRM5KDRMAPT | |
| SCHEMBL8629482 | 0.74 | PTGER1 (0.49) | GRM5MAPTL3MBTL1 | |
| SCHEMBL9713058 | 0.71 | MAPK14 (0.66) | RAF1MAPK14ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8721109 | 0.69 | F2 (0.44) | GRM5L3MBTL1 | |
| SCHEMBL5426692 | 0.69 | KDR (0.51) | RAF1MAPK14MAPK13BRAFALDH1A1 | |
| SCHEMBL9017144 | 0.69 | GRM5 (0.38) | GRM5MAPTL3MBTL1HRH3 | |
| SCHEMBL5422292 | 0.69 | RAF1 (0.50) | RAF1MAPK14MAPK13BRAFALDH1A1 | |
| SCHEMBL5575779 | 0.69 | BRAF (0.57) | RAF1MAPK14MAPK13BRAFALDH1A1 | |
| SCHEMBL9712723 | 0.67 | ALDH1A1 (0.57) | RAF1MAPK14MAPK13BRAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765789-B2 | 2-pyridinecarboxamide derivatives | MSD K.K. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2013-04-04 | — | — | US | disclosed |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2010-02-18 | — | — | US | disclosed |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | RAF1 747/4885MAPK14 533/4885MAPK13 456/4885 |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | GCKR, GCK, HK2 | RAF1 719/4885MAPK14 529/4885MAPK13 464/4885 |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | RAF1 747/4885MAPK14 533/4885MAPK13 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.