⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2663978 | 0.82 | — | — | |
| SCHEMBL2663968 | 0.79 | NLRP3 (0.36) | — | |
| SCHEMBL4724968 | 0.77 | — | — | |
| SCHEMBL18194627 | 0.76 | — | — | |
| SCHEMBL2663971 | 0.76 | — | — | |
| SCHEMBL2663976 | 0.76 | ITGB1 (0.41) | — | |
| SCHEMBL6440087 | 0.73 | — | — | |
| SCHEMBL2663972 | 0.73 | — | — | |
| SCHEMBL2663986 | 0.73 | NFKB1 (0.37) | — | |
| SCHEMBL2663994 | 0.71 | NFKB1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119230801-B | Lithium iron phosphate positive electrode material, preparation method thereof and lithium ion battery | 广东邦普循环科技有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-110483413-B | Process for the preparation of carbocyclic sugar derivatives | 百缮药业(苏州)有限公司 | 2023-02-28 | — | — | CN | disclosed |
| EP-4112604-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHIDROXY-3-HYDROXY-METHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | Ocuphire Pharma, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| CN-107474034-B | Process for the preparation of carbocyclic sugar derivatives | 瑞沙恩医药公司 | 2020-06-30 | — | — | CN | disclosed |
| EP-3246320-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHYDROXY-3- HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | REXAHN PHARMACEUTICALS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3378855-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHIDROXY-3-HYDROXY-METHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | Rexahn Pharmaceuticals, Inc. (US) | 2018-09-26 | — | — | EP | disclosed |
| EP-2970147-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | REXAHN PHARMACEUTICALS INC (US) | 2018-05-30 | — | — | EP | disclosed |
| US-9920016-B2 | Process for the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one | REXAHN PHARMACEUTICALS, INC. (US) | 2018-03-20 | — | — | US | disclosed |
| EP-3246320-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHYDROXY-3- HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | Rexahn Pharmaceuticals, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |
| US-20170158662-A1 | Process for the Preparation of 4-Amino-1-((1S,4R,5S)-2-Fluoro-4,5-Dihydroxy-3-Hydroxymethyl-Cyclopent-2-Enyl)-1H-Pyrimidin-2-One | REXAHN PHARMACEUTICALS, INC. (US) | 2017-06-08 | — | — | US | disclosed |
| EP-1537066-B1 | CYCLOPENTENONE DERIVATIVES AS POTENT ACTIVATORS OF HSF-1 | BIOGEM S C AR L (IT) | 2017-01-25 | — | — | EP | disclosed |
| US-9533958-B2 | Process or the preparation of 4-amino 1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-Enyl)-1H-pyrimidin-2-one | REXAHN PHARMACEUTICALS, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| EP-2970147-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | Rexahn Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150376142-A1 | Process for the Preparation of 4-Amino-1-((1S,4R,5S)-2-Fluoro-4,5-Dihydroxy-3-Hydroxymethyl-Cyclopent-2-Enyl)-1H-Pyrimidin-2-One | Ocuphire Pharma, Inc. | 2015-12-31 | — | — | US | disclosed |
| US-9150520-B2 | Process for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one | REXAHN PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| WO-2014145807-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R, 5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | REXAHN PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140275537-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-1-((1S,4R,5S)-2-FLUORO-4,5-DIHYDROXY-3-HYDROXYMETHYL-CYCLOPENT-2-ENYL)-1H-PYRIMIDIN-2-ONE | REXAHN PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8796313-B2 | Substituted dihydroisoindolones as allosteric modulators of glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-08-05 | — | — | US | disclosed |
| US-20070099930-A1 | Substituted Dihydroisoindolones As Allosteric Modulators of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | US | disclosed |