Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623091 | 0.88 | BTK (0.41) | SRCBRAFKDRTHRBTGFBR1 | |
| SCHEMBL26645414 | 0.88 | BTK (0.41) | SRCBRAFKDRTHRBTGFBR1 | |
| SCHEMBL26645621 | 0.88 | MAPK14 (0.40) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL26645097 | 0.88 | MAPK14 (0.40) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL30622868 | 0.88 | SRC (0.38) | SRCBRAFKDRTHRBTGFBR1 | |
| SCHEMBL26645448 | 0.86 | CPS1 (0.42) | BRAF | |
| SCHEMBL26645626 | 0.84 | MAPK9 (0.40) | SRCMAPK14MAPK11SMO | |
| SCHEMBL26645167 | 0.80 | SRC (0.43) | SRCBRAFKDRTHRBTGFBR1 | |
| SCHEMBL30622959 | 0.80 | SRC (0.41) | SRCBRAFKDRMAPK14MAPK13 | |
| SCHEMBL26645666 | 0.79 | SMO (0.34) | GAASMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |