Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26645720 | 0.89 | NR1H2 (0.44) | NR1H2JAK2JAK3GRM5JAK1 | |
| SCHEMBL26645416 | 0.87 | MAPT (0.53) | NR1H2JAK2JAK3GPR119JAK1 | |
| SCHEMBL26645173 | 0.86 | MAPT (0.52) | NR1H2JAK2JAK3GPR119JAK1 | |
| SCHEMBL23778205 | 0.82 | ATM (0.46) | NR1H2GRM5MAPK1ACHEKIT | |
| SCHEMBL26645437 | 0.82 | GALR2 (0.54) | NR1H2JAK2JAK3NAMPTJAK1 | |
| SCHEMBL30622856 | 0.82 | GALR2 (0.54) | NR1H2JAK2JAK3NAMPTJAK1 | |
| SCHEMBL30623068 | 0.81 | GALR2 (0.53) | NR1H2JAK2JAK3NAMPTJAK1 | |
| SCHEMBL26645091 | 0.81 | GALR2 (0.53) | NR1H2JAK2JAK3NAMPTJAK1 | |
| SCHEMBL12307580 | 0.81 | MEN1 (0.45) | NR1H2ACHE | |
| SCHEMBL12307411 | 0.80 | NR1H2 (0.45) | NR1H2GPR119GRM5MAPK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |