Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | JAK1 | P23458 | 7/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.41 |
| ▸ | GALR1 | P47211 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26645416 | 0.90 | MAPT (0.53) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL26645516 | 0.89 | NR1H2 (0.46) | NR1H2JAK2JAK1JAK3GRM5 | |
| SCHEMBL26645173 | 0.89 | MAPT (0.52) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL30622856 | 0.86 | GALR2 (0.54) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL26645437 | 0.86 | GALR2 (0.54) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL26645091 | 0.85 | GALR2 (0.53) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL30623068 | 0.85 | GALR2 (0.53) | NR1H2JAK2JAK1JAK3PTK2 | |
| SCHEMBL26645284 | 0.82 | MKNK1 (0.55) | NR1H2MKNK1MEN1KMT2A | |
| SCHEMBL16711314 | 0.81 | GRM5 (0.50) | NR1H2GRM5 | |
| SCHEMBL26645565 | 0.81 | MKNK1 (0.54) | NR1H2MKNK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |