Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26645416 | 0.99 | MAPT (0.53) | MAPTGPR119NR1H2JAK2JAK1 | |
| SCHEMBL26645720 | 0.89 | NR1H2 (0.44) | MAPTNR1H2JAK2JAK1JAK3 | |
| SCHEMBL26645516 | 0.86 | NR1H2 (0.46) | GPR119NR1H2JAK2JAK1JAK3 | |
| SCHEMBL26645091 | 0.83 | GALR2 (0.53) | MAPTNR1H2JAK2JAK1JAK3 | |
| SCHEMBL30623068 | 0.83 | GALR2 (0.53) | MAPTNR1H2JAK2JAK1JAK3 | |
| SCHEMBL26645437 | 0.82 | GALR2 (0.54) | MAPTNR1H2JAK2JAK1JAK3 | |
| SCHEMBL30622856 | 0.82 | GALR2 (0.54) | MAPTNR1H2JAK2JAK1JAK3 | |
| SCHEMBL26645099 | 0.81 | GRM5 (0.48) | MAPTGPR119NR1H2STSP2RY14 | |
| SCHEMBL26645738 | 0.78 | MAPT (0.50) | MAPTGPR119JAK2JAK1TGFBR1 | |
| SCHEMBL26645565 | 0.78 | MKNK1 (0.54) | GPR119NR1H2STSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519265-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |