Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623123 | 0.89 | GRM5 (0.43) | GRM5USP30HTTNR1H2MGAT2 | |
| SCHEMBL26645030 | 0.88 | HTT (0.55) | GRM5HTTNR1H2KDM4EHPGD | |
| SCHEMBL16711195 | 0.86 | GRM5 (0.50) | GRM5NR1H2 | |
| SCHEMBL30622995 | 0.82 | CFTR (0.44) | GRM5HTTNR1H2KDM4EHPGD | |
| SCHEMBL26645025 | 0.82 | CFTR (0.44) | GRM5HTTNR1H2KDM4EHPGD | |
| SCHEMBL30622947 | 0.82 | CFTR (0.44) | GRM5HTTNR1H2MEN1KMT2A | |
| SCHEMBL26645632 | 0.82 | CFTR (0.44) | GRM5HTTNR1H2MEN1KMT2A | |
| SCHEMBL30623033 | 0.81 | GRM5 (0.45) | GRM5MKNK1 | |
| SCHEMBL16711314 | 0.81 | GRM5 (0.50) | GRM5HTTNR1H2 | |
| SCHEMBL26645578 | 0.81 | GRM5 (0.50) | GRM5NR1H2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |