Amiloxate

Amiloxate

SCHEMBL26646558

CCCCC(CC)COC(=O)C(C#N)=C(c1ccccc1)c1ccc(OC)cc1.COc1ccc(C=CC(=O)OCCC(C)C)cc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.64
LMNA P02545 3/20 0.64
MAPK1 P28482 1/20 0.64
TDP1 Q9NUW8 3/20 0.60
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
TAS1R3 Q7RTX0 2/20 0.39
TAS1R1 Q7RTX1 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP3A4 P08684 2/20 0.37
BCHE P06276 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
CA2 P00918 1/20 0.36
ESR1 P03372 1/20 0.36
TRPM8 Q7Z2W7 2/20 0.35
CASP3 P42574 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amiloxate SCHEMBL26646557 1.00 ALDH1A1 (0.64) ALDH1A1LMNAMAPK1TDP1MEN1
Octocrylene SCHEMBL1655403 0.93 LMNA (0.71) ALDH1A1LMNAMAPK1TDP1MEN1
Octocrylene SCHEMBL28166919 0.91 LMNA (0.64) ALDH1A1LMNAMAPK1TDP1MEN1
Octocrylene SCHEMBL5160335 0.88 ALDH1A1 (0.51) ALDH1A1LMNAMAPK1TDP1MEN1
SCHEMBL16762811 0.86 ALDH1A1 (0.86) ALDH1A1LMNAMAPK1TDP1CYP3A4
SCHEMBL346933 0.86 ALDH1A1 (0.86) ALDH1A1LMNAMAPK1TDP1CYP3A4
SCHEMBL469376 0.86 ALDH1A1 (0.86) ALDH1A1LMNAMAPK1TDP1CYP3A4
SCHEMBL21908164 0.86 ALDH1A1 (0.86) ALDH1A1LMNAMAPK1TDP1CYP3A4
Octinoxate SCHEMBL20787052 0.83 TDP1 (0.85) ALDH1A1LMNATDP1TAS1R3TAS1R1
SCHEMBL10067446 0.80 ALDH1A1 (0.74) ALDH1A1LMNAMAPK1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4392144-A1 SUNSCREEN COMPOSITION COMPRISING: A METAL OXIDE, SPF ACTIVE INGREDIENT; AND ONE OR MORE SPF ENHANCEMENT COMPONENT COMPRISING A PHOTOSTABILIZER, AN ANTIOXIDANT, OR A COMBINATION THEREOF Colgate-Palmolive Company (US) 2024-07-03 EP disclosed
WO-2023224944-A1 SUNSCREEN COMPOSITION COMPRISING: A METAL OXIDE, SPF ACTIVE INGREDIENT; AND ONE OR MORE SPF ENHANCEMENT COMPONENT COMPRISING A PHOTOSTABILIZER, AN ANTIOXIDANT, OR A COMBINATION THEREOF COLGATE-PALMOLIVE COMPANY (US) 2023-11-23 WO disclosed
US-20230364005-A1 Sunscreen Compositions and Methods of Use COLGATE-PALMOLIVE COMPANY (US) 2023-11-16 US disclosed