Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22315254 | 0.92 | NPC1 (0.47) | CRBNARNPC1RAB9ACTSK | |
| SCHEMBL20707943 | 0.90 | NPC1 (0.50) | CRBNARNPC1RAB9ACTSK | |
| SCHEMBL5563460 | 0.87 | CRBN (0.49) | CRBNARNPC1RAB9ACTSK | |
| SCHEMBL18499513 | 0.81 | CRBN (0.41) | CRBNARNPC1RAB9ACTSK | |
| SCHEMBL21161176 | 0.80 | CRBN (0.43) | CRBNARNPC1RAB9ACTSK | |
| SCHEMBL5567577 | 0.79 | PRMT3 (0.47) | CRBNNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL24010681 | 0.78 | NPC1 (0.43) | ARNPC1RAB9ACTSKSMN1; SMN2 | |
| SCHEMBL2054713 | 0.78 | CRBN (0.51) | CRBNARRAB9ACTSKSMN1; SMN2 | |
| SCHEMBL2665515 | 0.77 | ALDH1A1 (0.50) | CRBNARNPC1RAB9AALDH1A1 | |
| SCHEMBL20738282 | 0.76 | AR (0.45) | CRBNARNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003048109-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002000612-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | WO | disclosed |