Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 11/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 4/20 | 0.33 |
| ▸ | CDK4 | P11802 | 4/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.33 |
| ▸ | CCND1 | P24385 | 4/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.31 |
| ▸ | CIT | O14578 | 1/20 | 0.31 |
| ▸ | CASK | O14936 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PAK3 | O75914 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665339 | 1.00 | CDK2 (0.35) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2649802 | 0.87 | CDK2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL13639772 | 0.85 | CDK2 (0.37) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL9072537 | 0.85 | CDK2 (0.37) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2665346 | 0.85 | CDK2 (0.37) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL1000423 | 0.84 | CDK2 (0.38) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL1000421 | 0.84 | CDK2 (0.38) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2665341 | 0.83 | CDK2 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2665326 | 0.83 | CDK2 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2648404 | 0.83 | RAB9A (0.43) | CDK2CCNE2CCNE1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | CDK2 253/4885CCNE2 2474/4885CCNE1 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.